Topic · 5 episodes
Health
Health in 2024 is being reshaped by precision medicine across several fronts. Onpode's coverage spans gene therapy for hereditary angioedema, a non-hormonal menopause treatment reducing hot flashes and mood symptoms, an oral GLP-1 pill delivering meaningful weight loss and blood sugar control, and the FDA's first targeted approval for PTEN-deficient prostate cancer. The through-line: treatments engineered for defined patient populations.
Frequently asked
What are the Phase 3 results for Intellia's lonvo-z gene therapy?
Intellia's lonvo-z posted strong Phase 3 results for hereditary angioedema treatment. The data marked a significant milestone for gene therapy in this rare genetic condition, suggesting lonvo-z could offer a durable intervention for patients managing hereditary angioedema.
Is there a menopause treatment that works without hormones?
A non-hormonal menopause treatment has shown in trials that it can reduce hot flashes, anxiety, and depression without the risks associated with hormone replacement therapy. This offers a meaningful alternative for people who cannot or prefer not to use HRT.
Can a pill replace injectable GLP-1 drugs for diabetes and weight loss?
A new GLP-1 diabetes pill has achieved significant weight loss and blood sugar control in clinical trials, suggesting an effective oral pill could be a viable alternative to injectable GLP-1 therapies for patients managing type 2 diabetes and obesity.
What is AstraZeneca's Truqap and what did the FDA approve it for?
AstraZeneca's Truqap received FDA approval as the first and only targeted treatment for PTEN-deficient prostate cancer. This approval represents a precision oncology advance, giving clinicians a specifically indicated option for a prostate cancer subgroup defined by PTEN loss.
Episodes
Why your body resists change — the feedback loops that keep you aliveHomeostasis — named by Walter Cannon in 1926, conceived by Claude Bernard in 1865 — keeps blood glucose between 70–110 mg/dL and core temperature near 37°C through negative feedback loops: sensor, control center, set point, effector. During infection, the hypothalamus raises its set point, making a fever the defended value, not the malfunction.
Intellia's lonvo-z gene therapy posted strong Phase 3 results for hereditary angioedema treatment
A non-hormonal menopause treatment just reduced hot flashes, anxiety, and depression without HRT risks
A new GLP-1 diabetes pill just achieved major weight loss and blood sugar control in trials
AstraZeneca's Truqap just won FDA approval as the first and only targeted treatment for PTEN-deficient prostate cancer